Sensorion Provides Update on Hearing Loss Gene Therapies
The company highlights progress in its SENS-501 and GJB2-GT clinical programs, recent financing, and a leadership transition.
Category: Sensorineural
Sensorineural
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Sensorineural
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Researchers Advance Gene Therapy for CLIC5-Related Inner Ear Dysfunction
The therapy targets mutations in the CLIC5 gene, which affect hair cell stability and lead to progressive hearing and balance impairments.
Sensorineural
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Gold Standard Treatment for Sudden Sensorineural Hearing Loss
In this case study, a man with hearing loss after a stroke benefits from hyperbaric oxygen therapy and steroid treatments.
COVID-19 Associated with Hearing Loss, Study Shows
Hearing loss and other auditory problems are strongly associated with COVID-19 according to a systematic review of research evidence.
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Published Review Links SARS-CoV-2 to Middle Ear Infections, Hearing Loss
The researchers concluded that “SARS‐CoV‐2 is a probable cause of middle ear infections and sensorineural hearing loss, secondary to spread of the novel virus into the middle ear and related neural structures.”
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‘BMJ’ Publishes ‘First Reported UK Case’ of Sudden Hearing Loss Linked to COVID-19
The doctors describe a case of a 45-year-old man with asthma who was referred to the ear, nose, and throat department at their hospital after suddenly experiencing hearing loss in one ear while being treated for COVID-19 infection as an inpatient.
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BIHIMA Survey Finds 1 in 6 UK Adults Have Hearing Loss
In a recent survey of 2,000 UK adults, commissioned by the British Irish Hearing Instrument Manufacturers Association (BIHIMA) and announced on its website, 16% of respondents self-reported suffering from hearing loss, with men being nearly twice as likely to suffer as women: 1 in 5 men reported suffering from hearing loss compared to 1 in 10 women.
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Researchers Explain Link Between Hearing Loss, Dementia
Scientists consider explanations for how changes in brain activity due to hearing loss might directly promote the presence of abnormal proteins that cause Alzheimer’s disease, therefore triggering the disease.
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Plural Publishing Releases 2nd Edition of ‘Disorders of the Auditory System’
The book by Frank Musiek, Jennifer Shinn, Jane Baran, and Raleigh Jones provides the reader with both the audiologic and medical aspects of auditory dysfunction associated with disorders of the peripheral and central auditory system.
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Research Shows Hair Cell Damage May Be Main Cause of Age-related Hearing Loss
Researchers examined 120 inner ears collected at autopsy. They used multivariable statistical regression to compare data on the survival of hair cells, nerve fibers, and the stria vascularis with the patients’ audiograms to uncover the main predictor of the hearing loss in this aging population. They found that the degree and location of hair cell death predicted the severity and pattern of the hearing loss, while stria vascularis damage did not.
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What Is “Normal Hearing” for Older Adults and Can “Normal-hearing Older Adults” Benefit from Hearing Care Intervention?
Researcher and author Larry Humes, PhD, points out that large-scale studies have identified self-reported hearing difficulties as one of the strongest predictors of hearing aid uptake and use. He says this further reinforces the need for the older consumer and the hearing care professional to quantify the severity of hearing difficulties above and beyond those captured by the pure-tone audiogram.
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BBC Looks at How Loud Music Can Lead to Early Signs of Hearing Damage
The article examined a study from researchers at the University of Manchester, which suggests that although the damage observed is not enough to be diagnosed as a full-blown hearing loss, it could potentially have a cumulative effect on hearing later in life.
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Researchers Look at Potential Link between Coronavirus and Hearing Loss
The authors point out that coronaviruses, in some cases, can cause peripheral neuropathy, and, ”in theory..COVID-19 could cause auditory neuropathy, a hearing disorder where the cochlea is functioning but transmission along the auditory nerve to the brain is impaired.”
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The Musicians’ Clinics of Canada Launches New Website
MusiciansClinics.com is a resource for those seeking information on a variety of topics related to hearing and hearing loss in musicians. Developed by audiologist-musician Marshall Chasin, AuD, the website offers a large range of resources for guitarists, bass players, violinists, woodwind players, school band teachers, and more.
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USC Stem Cell Study Traces Evolution of Organ of Corti
By the time mice are born, the progenitor cells in the Organ of Corti have finished both proliferation and differentiation, and cannot regenerate if they are damaged—causing permanent hearing loss.
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Age-related Hearing Loss Genes Discovered in Fruit Flies
“Our twin discoveries that fruit flies experience age-related hearing loss and that their prior auditory health is controlled by a particular set of genes, is a significant breakthrough. The fact that these genes are conserved in humans will also help to focus future clinical research in humans and thereby accelerate the discovery of novel pharmacological or gene-therapeutic strategies,” says lead-author Joerg Albert.
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Age-related Hearing Loss May Reorganize Brain’s Sensory Areas
Researchers looked at mice engineered to have progressive hearing loss, and found that their neurotransmitter receptors—responsible for communication between brain cells—exhibited changes in sensory processing regions related to memory.
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Researchers Chart Development of Cells from Mouse Cochlea
In the future, scientists may be able to use the data to steer stem cells toward the hair cell lineage, helping to produce the specialized cells they need to test cell replacement approaches for reversing some forms of hearing loss.
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