Evaxion Presents New Preclinical Data for AI-Designed CMV Vaccine Program EVX-V1
New preclinical findings show AI-discovered T-cell epitopes may improve control of CMV infection.
Category: Sensorineural
Sensorineural
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Sensorineural
Latest
FDA Expediting Review of Regeneron Drug to Treat Genetic Hearing Loss
Regeneron’s DB-OTO gene therapy for genetic hearing loss is one of nine drugs to receive expedited review under FDA's new CNPV program.
Sensorineural
Latest
Sensorion Announces Positive Data from Audiogene SENS-501 Clinical Trial
Sensorion’s Phase 1/2 Audiogene trial of the gene therapy SENS-501 for infants and toddlers with OTOF-related congenital deafness shows promising early safety and hearing improvement data, particularly in one patient, with a higher dose cohort now underway.
Akouos’ AK-OTOF Receives Orphan Drug Designation
Akouos, Inc announced that the European Medicines Agency (EMA) Committee for Orphan Medicinal Products (COMP) issued a positive opinion on the company’s application for orphan drug designation for AK-OTOF, a gene therapy intended for the treatment of otoferlin gene-mediated hearing loss. The positive opinion was subsequently adopted by the European Commission.
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AARP Article Cites Reasons to Treat Hearing Loss
The article mentions the brain changes that studies have shown may happen when hearing loss remains untreated, potentially causing visual and sensory processing centers to access the auditory cortex, which can result in deterioration of the cortex over time.
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Delta Variant of COVID-19 May Cause Hearing Loss
Hearing impairment, blood clots leading to gangrene, and “severe gastric upsets,” are being seen by doctors in India, England, and Scotland, where the B.1.617.2 delta strain is prevalent and more likely to lead to hospitalization, Bloomberg reported.
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COVID-19 Associated with Hearing Loss, Study Shows
Hearing loss and other auditory problems are strongly associated with COVID-19 according to a systematic review of research evidence.
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Published Review Links SARS-CoV-2 to Middle Ear Infections, Hearing Loss
The researchers concluded that “SARS‐CoV‐2 is a probable cause of middle ear infections and sensorineural hearing loss, secondary to spread of the novel virus into the middle ear and related neural structures.”
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‘BMJ’ Publishes ‘First Reported UK Case’ of Sudden Hearing Loss Linked to COVID-19
The doctors describe a case of a 45-year-old man with asthma who was referred to the ear, nose, and throat department at their hospital after suddenly experiencing hearing loss in one ear while being treated for COVID-19 infection as an inpatient.
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BIHIMA Survey Finds 1 in 6 UK Adults Have Hearing Loss
In a recent survey of 2,000 UK adults, commissioned by the British Irish Hearing Instrument Manufacturers Association (BIHIMA) and announced on its website, 16% of respondents self-reported suffering from hearing loss, with men being nearly twice as likely to suffer as women: 1 in 5 men reported suffering from hearing loss compared to 1 in 10 women.
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Researchers Explain Link Between Hearing Loss, Dementia
Scientists consider explanations for how changes in brain activity due to hearing loss might directly promote the presence of abnormal proteins that cause Alzheimer’s disease, therefore triggering the disease.
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Plural Publishing Releases 2nd Edition of ‘Disorders of the Auditory System’
The book by Frank Musiek, Jennifer Shinn, Jane Baran, and Raleigh Jones provides the reader with both the audiologic and medical aspects of auditory dysfunction associated with disorders of the peripheral and central auditory system.
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Research Shows Hair Cell Damage May Be Main Cause of Age-related Hearing Loss
Researchers examined 120 inner ears collected at autopsy. They used multivariable statistical regression to compare data on the survival of hair cells, nerve fibers, and the stria vascularis with the patients’ audiograms to uncover the main predictor of the hearing loss in this aging population. They found that the degree and location of hair cell death predicted the severity and pattern of the hearing loss, while stria vascularis damage did not.
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What Is “Normal Hearing” for Older Adults and Can “Normal-hearing Older Adults” Benefit from Hearing Care Intervention?
Researcher and author Larry Humes, PhD, points out that large-scale studies have identified self-reported hearing difficulties as one of the strongest predictors of hearing aid uptake and use. He says this further reinforces the need for the older consumer and the hearing care professional to quantify the severity of hearing difficulties above and beyond those captured by the pure-tone audiogram.
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BBC Looks at How Loud Music Can Lead to Early Signs of Hearing Damage
The article examined a study from researchers at the University of Manchester, which suggests that although the damage observed is not enough to be diagnosed as a full-blown hearing loss, it could potentially have a cumulative effect on hearing later in life.
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Researchers Look at Potential Link between Coronavirus and Hearing Loss
The authors point out that coronaviruses, in some cases, can cause peripheral neuropathy, and, ”in theory..COVID-19 could cause auditory neuropathy, a hearing disorder where the cochlea is functioning but transmission along the auditory nerve to the brain is impaired.”
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The Musicians’ Clinics of Canada Launches New Website
MusiciansClinics.com is a resource for those seeking information on a variety of topics related to hearing and hearing loss in musicians. Developed by audiologist-musician Marshall Chasin, AuD, the website offers a large range of resources for guitarists, bass players, violinists, woodwind players, school band teachers, and more.
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USC Stem Cell Study Traces Evolution of Organ of Corti
By the time mice are born, the progenitor cells in the Organ of Corti have finished both proliferation and differentiation, and cannot regenerate if they are damaged—causing permanent hearing loss.
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