Tag: age-related hearing loss

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A 10-Year Review of the Earlens System, Part 3: What’s the Big Deal about Audibility and Broader Audible Bandwidth?

This 3-part series is a high-level review of the data that has accumulated across more than 10 years of clinical research with the technology at the heart of the Earlens system. In Part 1, we dove into the speech understanding data to demonstrate how increasing the audible bandwidth of processed sound results in improved speech understanding performance from several perspectives. In Part 2, we discussed the perceptual benefits to naturalness and overall sound quality. Finally, in Part 3, we’ll deep dive into the restoration of audibility and how the Earlens approach to overall audibility improvement is reliably achieved in fittings via direct drive—as well as who may benefit from this. 

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Frequency Therapeutics Reports Disappointing Trial Results for Hearing Restoration Drug

Frequency Therapeutics announced topline results from its recent study, showing that four weekly injections of its FX-322 treatment therapy in subjects with mild to moderately severe sensorineural hearing loss (SNHL) did not demonstrate improvements in hearing measures versus placebo. FX-322, the company's lead product candidate, made news last month when a study published in 'Otology & Neurotology' indicated the “first known linkage of pharmacokinetics and pharmacodynamics for a potential hearing restoration therapy.”

Research Shows Hair Cell Damage May Be Main Cause of Age-related Hearing Loss

Researchers examined 120 inner ears collected at autopsy. They used multivariable statistical regression to compare data on the survival of hair cells, nerve fibers, and the stria vascularis with the patients’ audiograms to uncover the main predictor of the hearing loss in this aging population. They found that the degree and location of hair cell death predicted the severity and pattern of the hearing loss, while stria vascularis damage did not.

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Age-related Hearing Loss Genes Discovered in Fruit Flies

“Our twin discoveries that fruit flies experience age-related hearing loss and that their prior auditory health is controlled by a particular set of genes, is a significant breakthrough. The fact that these genes are conserved in humans will also help to focus future clinical research in humans and thereby accelerate the discovery of novel pharmacological or gene-therapeutic strategies,” says lead-author Joerg Albert.

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How Might the Brain Change When We Reintroduce Sound? Interview with Anu Sharma, PhD

New research shows that after wearing professionally fit quality hearing aids, a patient’s brain may “re-organize” its auditory processing centers back towards its original state prior to the hearing loss—with corresponding gains in auditory speech perception abilities and improvements in global cognitive function, executive function, processing speed, and visual working memory performance. Anu Sharma discusses the research findings with Douglas Beck.

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