Compound AC102 Shows Promise in Restoring Noise-Induced Hearing Loss
A single application of the novel compound AC102 almost completely restores noise-induced hearing loss in preclinical models.
Tag: inner ear
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UPenn Researchers ID New Cause of Hearing Loss
A gene called GAS2 plays a key role in normal hearing, and its absence causes severe hearing loss, according to a study led by researchers in the Perelman School of Medicine at the University of Pennsylvania.
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NIDCD Scientific Director, Andrew Griffith, Steps Down
A geneticist and otolaryngologist–head and neck surgeon, Griffith has spent two decades as a principal investigator at the National Institute on Deafness and Other Communication Disorders (NIDCD), during which he led the NIDCD intramural program as the scientific director for 11 years.
Sensorion Appoints John Furey As Independent Board Member
Furey was most recently Chief Operating Officer (COO) for Spark Therapeutics, a global gene therapy developer. This appointment will be effective at the next meeting of the board of directors of the company, in September 2019.
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Newport-Mesa Audiology Balance & Ear Institute to Present on Dizziness Treatments at AAA 2019
The clinicians will outline how they perform comprehensive balance evaluations and various methods of vestibular rehabilitation, including the use of virtual reality, in an audiology setting. They will also discuss outcome statistics following treatment and share case studies.
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Researchers Find New Genetic Mutations Associated with Usher Syndrome
Usher syndrome is an inherited disorder that reportedly accounts for almost half of all cases of deaf-blindness. There are three types of the disease that are differentiated based on the level of deafness (Type I – innate deafness; Type II – diminished hearing that does not worsen with time, and Type III -progressive decrease in hearing).
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Researchers Map Functioning of Inner Ear
A team led by Professor Karen B. Avraham, vice dean of the Sackler Faculty of Medicine at Tel Aviv University, has now created the first map of “methylation”–one of the body’s main epigenetic signals–that reflects the functioning of the inner ear in its entirety.
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Composing with Hearing Loss
Composing music when you have a severe hearing loss can be a real challenge. For example, one has to listen with high acuity to the musical tracks using headphones or in-ear monitors that, by nature, make hearing aid use very difficult or impossible. Here are some insights from an accomplished composer who has devised several solutions for the creation of great music.
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Harvard Medical School Researchers Find Sensory Protein Linked to Hearing and Balance
The results of their research, reported August 22 in “Neuron,” reveal that TMC1, a protein discovered in 2002, forms a sound- and motion-activated pore that allows the conversion of sound and head movement into nerve signals that travel to the brain—a signaling cascade that enables hearing and balance.
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Akouos Raises $50 Million in Series A Financing; Forms Scientific Advisory Board
Akouos is developing targeted adeno-associated viral vector (AAV)-based gene therapies for sensorineural hearing loss, which results from dysfunction or damage to sensory cells and/or nerve fibers of the inner ear.
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Sensorion Announces Initiation of Phase 2 Study for Vertigo Drug Seliforant
By comparing the effects of seliforant to meclizine, a drug with known anticholinergic side effects, and placebo, the SENS-111-202 study aims to confirm the absence of anticholinergic effects such as sedation and memory loss in patients receiving seliforant.
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New Research Pinpoints Mechanism Behind Sound-Induced Vertigo
It has been estimated that 1 in 100 people around the world have a congenital inner ear condition known as semicircular canal dehiscence, a thinning of the bone enclosing the inner ear that can lead to vertigo in response to certain sounds, changes in atmospheric pressure, or coughing.
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Sensorion Presents SENS-401 Data at Ci2018 Conference
Data from the presented studies showed that SENS-401 protected inner ear function and enhanced sensory hair cell survival in preclinical models of acoustic trauma and, separately, cisplatin infusion.
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NIH Researchers Find Link Between Cisplatin Build-up and Hearing Loss
Using a highly sensitive technique to measure and map cisplatin in mouse and human inner ear tissues, researchers found that forms of cisplatin build up in the inner ear.
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NIDCD Researchers Study Protein’s Effect on Inner Ear Development
Conducted by scientists at NIDCD—part of the National Institutes of Health (NIH)—the research offers new insight into how specialized sensory hair cells develop and function, providing opportunities for scientists to explore novel ways to treat hearing loss, balance disorders, and deafness.
Read MoreNIDCD to Present Communication Disorder Series ‘The Making of the Inner Ear’
Doris Wu, PhD, chief of the NIDCD Laboratory of Molecular Biology and the Section on Sensory Cell Regeneration and Development, will present the next talk in the NIDCD’s Beyond the Lab, Understanding Communication Disorders speaker series.
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Inner Ear Tissue Grown from Human Stem Cells
Researchers at Indiana University School of Medicine have successfully developed a method to grow inner ear tissue from human stem cells—a finding that could lead to new platforms to model disease and new therapies for the treatment of hearing and balance disorders.
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Auris Announces FDA Fast Track Designation For AM-111
Auris Medical Holding AG has been granted Fast Track designation by the FDA for the company’s AM-111 for the treatment of acute sensorineural (inner ear) hearing loss.
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