Tag: SNHL

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Frequency Therapeutics Announced Full Year 2021 Financial Results

Frequency Therapeutics, Inc, a clinical-stage regenerative medicine company focused on developing therapeutics to activate a person’s innate regenerative potential to restore function, announced business updates and financial results for the fourth quarter and full year ended December 31, 2021.

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Frequency Therapeutics Reports Disappointing Trial Results for Hearing Restoration Drug

Frequency Therapeutics announced topline results from its recent study, showing that four weekly injections of its FX-322 treatment therapy in subjects with mild to moderately severe sensorineural hearing loss (SNHL) did not demonstrate improvements in hearing measures versus placebo. FX-322, the company's lead product candidate, made news last month when a study published in 'Otology & Neurotology' indicated the “first known linkage of pharmacokinetics and pharmacodynamics for a potential hearing restoration therapy.”

Dichotic Listening in Elderly, Hearing-Impaired Persons: An Exercise in Pattern Recognition

It is well known that a patient’s audiometric configuration does not, and cannot, always describe the true impact of a hearing loss. Sensorineural hearing loss (SNHL) is often accompanied by a decline in cognitive function and/or deficits in central auditory processing. This article by James Jerger, PhD, shows how the Dichotic Sentence Identification (DSI) Test can help differentiate between simple SNHL and those hearing losses involving cognitive decline or auditory processing disorder (APD) in older adults.

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Effects of Amplification on Cortical Electrophysiological Function

There has been great interest in using speech-evoked cortical auditory evoked potentials (CAEP) as an objective hearing aid validation measure, because CAEPs allow us to assess the audibility of speech sounds at the highest (cortical) levels. Here is a review by Sridhar Krishnamurti and Larry Wise, as well as results from a study they conducted that suggests there is clinical value of CAEPs for assessing cortical changes from amplification, as well as using this data in audiology services to demonstrate patient benefit.

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Auditory Deprivation, Brain Changes Secondary to Hearing Loss, and More: An Interview with Anu Sharma, PhD

For this installment of Inside Clinical Research, Dr Doug Beck discusses with researcher Anu Sharma, PhD, her work in cross modal plasticity of the brain and cortical resource allocation as related to hearing loss. Dr Sharma also discusses other aspects of auditory deprivation on the human brain.

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