Researchers have discovered a gene region that raises the risk a child will have a middle ear infection, known to doctors as acute otitis media (AOM). The finding may offer an early clue to helping develop more effective treatments to prevent one of the most common, and painful childhood illnesses.
“Parents and pediatricians are all too familiar with painful childhood ear infection—it’s the most frequent reason children receive antibiotics,” said study leader Hakon Hakonarson, MD, PhD, director of the Center for Applied Genomics at The Children’s Hospital of Philadelphia (CHOP). “Although microbes cause this condition, it’s been well known that genetics also plays a role. This is the first and largest genetic study focused on risk susceptibility for acute otitis media.”
According to CHOP, Hakonarson and colleagues collaborated with Dutch researchers led by Gijs van Ingen, PhD, and colleagues from the University Medical Center, Rotterdam, in the study published online in the September 28, 2016 edition of Nature Communications.
The researchers performed a genome-wide association study (GWAS) on two discovery cohorts with DNA samples from 11,000 children. They found an association between AOM and a site on chromosome 6 containing the gene FNDC1, and then replicated the finding in an independent pediatric cohort with data from 2,000 children. Co-first author Jin Li, PhD, of CHOP, was the lead analyst on the study.
CHOP reports that in further studies, the scientists showed that the mouse gene corresponding to FNDC1 was expressed in the animal’s middle ear.
“Although the gene’s function in humans has not been well studied, we do know that FNDC1 codes for a protein with a role in inflammation,” said Hakonarson.
Hakonarson added that by increasing our understanding of the biological interactions between genes and pathogens involved in AOM, researchers may be able to develop more specific therapies for childhood ear infection, while learning which children are most susceptible to the disease. The investigators say that, as with many other diseases, early medical intervention may offer the greatest benefits.
Source: The Children’s Hospital of Philadelphia (CHOP); “Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene,” Nature Communications, published online Sept. 28, 2016: http://doi.org/10.1038/ncomms12792