New Findings Pave the Way for Hearing Loss Therapies
Researchers are developing new hearing loss therapies by studying the role the mTORC2-signaling pathway plays for inner ear hair cells.
Tag: hair cells
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Researchers ID Role of Deafness Gene in Norrie Disease
The researchers found that the Norrie Disease Protein (NDP), which is lacking in patients with the rare disease, is essential for the maintenance and survival of hair cells in the cochlea, the cells responsible for hearing.
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University of Colorado Researchers Challenge Sensory Cell Sound Detection
First published in 1987, the prevailing model for how adaptation works asserted that the sound-sensitive “antenna” of the hair cell (called the hair bundle) undergoes a mechanical change during adaptation, such that a decrease in stiffness of the hair bundle caused a decrease in MET sensitivity.
Researchers Study Link Between Hair Cells and Genetic Factors in Zebrafish
Using zebrafish as a proxy, scientists have shed light on how changes to specific genes alter the coordinated direction that these cells are laid out.
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Frequency Therapeutics Announces Hearing Loss Drug Has FDA Fast-Track Designation
In a Phase 1/2 study, FX-322 demonstrated a statistically significant and clinically meaningful improvement in key measures of hearing loss, including clarity of sound and word recognition, with no serious adverse events observed.
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Purdue Researchers Find Noise-induced Trauma May Have Greater Impact on Hearing Loss
The researchers found that noise trauma causes substantially greater changes in neural processing of complex sounds compared with age-related metabolic loss, potentially explaining large differences in speech perception commonly seen between people with the same clinically defined degree of hearing loss based on an audiogram.
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Malaria Drug Could Help Prevent Form of Hereditary Hearing Loss
Using a zebrafish model, researchers at Case Western Reserve University School of Medicine have found that artemisinin, an anti-malarial drug, may help treat forms of hereditary hearing and vision loss associated with clarin1 mutations like Usher syndrome.
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Malaria Drug Could Help Prevent Form of Hereditary Hearing Loss
Using a zebrafish model, researchers at Case Western Reserve University School of Medicine have found that artemisinin, an anti-malarial drug, may help treat forms of hereditary hearing and vision loss associated with clarin1 mutations like Usher syndrome.
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Cold Spring Harbor Laboratory Press Releases ‘Function and Dysfunction of the Cochlea’
The book describes major advances in our understanding of the pathogenic processes underlying various forms of hearing loss and the emergence of treatments for deafness.
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Robert Fettiplace Named 2019 Passano Fellow for Hearing Research
Fettiplace, a professor of neuroscience at the University of Wisconsin School of Medicine and Public Health (UW SMPH), won the award for showing how cochlear hair cells sense the tiny mechanical vibrations that sound produces in the inner ear.
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Young Cancer Survivors with Severe Hearing Loss Experience Difficulties Learning to Read, Study Shows
After accounting for the risk factors of age at diagnosis and treatment intensity, the analysis suggested that survivors with severe hearing loss struggled the most with slowed processing speed and phonological skills.
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Researchers Identify 38 New Mouse Genes Related to Hearing Loss
To identify new molecules involved in hearing loss, the researchers took a genetic approach and created 1,211 new mouse mutants. They screened each of these mice using a sensitive electrophysiological test, the auditory brainstem response, to find out how good their hearing was.
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UVA Researchers Find Potential Contributor to Age-related Hearing Loss
The auditory receptors of the inner ear, called hair cells, pick up sounds using a vibration-sensing antenna called the hair bundle. While much research into hearing loss has focused on the hair bundle, UVA’s discovery spotlights the foundations those antennas stand on.
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Inner Ear Protein Mechanism for Sound Wave Conversion Identified
The researcher’s new work reveals the identity and mechanism of a finely-tuned spring they believe is responsible for converting the deflection of hair cells into a force capable of opening ion channels.
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MED-EL Announces Winner of Ideas4Ears Competition
The contest challenged children from around the world aged 6-12 years old to create an invention to improve the quality of life for people living with hearing loss.
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Researchers Map Functioning of Inner Ear
A team led by Professor Karen B. Avraham, vice dean of the Sackler Faculty of Medicine at Tel Aviv University, has now created the first map of “methylation”–one of the body’s main epigenetic signals–that reflects the functioning of the inner ear in its entirety.
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Oticon Study Finds Inner Ear Mechanism for Speech Processing
The research, conducted by researchers from Oticon and Interacoustics on an international team, revealed another function in the inner ear that detects the acoustic details in speech before it is converted into information for the brain.
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Otonomy Presents Data on OTO-413 Therapy for Hearing Loss
These preclinical data, demonstrating the potential of intratympanic BDNF to repair cochlear synaptopathy—an underlying cause of hearing loss including speech-in-noise hearing difficulty—are being presented as part of the Society for Neuroscience (SfN) Annual Meeting in San Diego, November 3-7, 2018.
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