Researchers at Karolinska Institutet have identified four types of neurons in the peripheral auditory system, three of which are new to science, the Sweden-based medical university announced on its website. The analysis of these cells is thought to be beneficial to the discovery of new therapies for various kinds of hearing disorders, such as tinnitus and age-related hearing loss.
When sound reaches the inner ear, it is converted into electrical signals that are relayed to the brain via the ear’s nerve cells in the cochlea. Previously, most of these cells were considered to be of two types: Type 1 and Type 2 neurons, with Type 1 transmitting most of the auditory information. The new study by scientists at Karolinska Institutet shows that the Type 1 cells actually comprise three very different cell types, which tallies with earlier research showing variations in the electrical properties and sonic response of Type 1 cells.
Three different routes
“We now know that there are three different routes into the central auditory system, instead of just one,” said François Lallemend, research group leader at the Department of Neuroscience, Karolinska Institutet, who led the study. “This makes us better placed to understand the part played by the different neurons in hearing. We’ve also mapped out which genes are active in the individual cell types.”
The team conducted their study on mice using the relatively new technique of single-cell RNA sequencing. The result is a catalog of the genes expressed in the nerve cells, which can give scientists a solid foundation for better understanding the auditory system as well as for devising new therapies and drugs.
“Our study can open the way for the development of genetic tools that can be used for new treatments for different kinds of hearing disorders, such as tinnitus,” said Lallemend. “Our mapping can also give rise to different ways of influencing the function of individual nerve cells in the body.”
The study shows that these three neuron types probably play a part in the decoding of sonic intensity (ie, volume), a function that is crucial during conversations in a loud environment, which rely on the ability to filter out the background noise. This property is also important in different forms of hearing disorders, such as tinnitus or hyperacusis (oversensitivity to sound).
“Once we know which neurons cause hyperacusis we’ll be able to start investigating new therapies to protect or repair them,” explained Lallemend. “The next step is to show what effect these individual nerve cells have on the auditory system, which can lead to the development of better auditory aids such as cochlear implants.”
The researchers have also shown through comparative studies on adult mice that these different types of neurons are already present at birth.
The study was financed by grants from the Swedish Research Council, the Knut and Alice Wallenberg Foundation (Wallenberg Academy Fellow), the Swedish Brain Fund, Karolinska Institutet, the Ragnar Söderberg Foundation, and the Silent School Foundation.
Original Paper: Petitpré C, Wu H, Sharma A, et al. Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system. Nature Communications. 2018;9(3691).
Source: Karolinska Institutet, Nature Communications
Images: Stefan Zimmerman, Karolinska Institutet