The findings, published in the American Journal of Human Genetics, cast doubt on the understanding that age-related hearing impairment originates mainly from sensory hair cells and propose the stria vascularis, a part of the cochlea in the ear, as a new target for treatments to help people with hearing loss. An article detailing the research appears on the King’s College London website.
Many people gradually lose some of their hearing ability as they get older, and an estimated 2.4 billion individuals will have some form of hearing loss by 2050. Age-related hearing impairment is a top contributor to years lived with disability and is also an important risk factor for dementia.
The team studied genetic analyses previously carried out in centers around the world using samples from 723,266 people from 17 studies who had clinically diagnosed or self-reported hearing impairment. This meta-analysis is one of the largest conducted in hearing genetics to date. The researchers identified 48 genes linked to hearing loss, including 10 new variants newly linked to hearing.
Further analysis looking at mouse genetics indicated that age-related hearing loss is due to changes in the stria vascularis, a part of the cochlea in the ear, which is necessary for hearing. The results provide targets for the basis of future research which could improve therapies against hearing loss.
“Our findings identify 10 genes newly linked with hearing loss. This study points to genes we could target for screening purposes, drug development ,and even gene therapy in the future. This study provides a solid foundation for ultimately improving therapies against hearing loss,” said co-main author Professor Frances Williams, from the School of Life Course & Population Sciences.
Co-main author Christopher R. Cederroth, associate professor at the Karolinska Institute, said: “It was hypothesized since the 1970s that the stria vascularis may play a role in hearing loss in humans, but the molecular evidence for this was missing until today.”
Original Paper: Trpchevska N, Freidin MB, Broer L, et al. Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss. American Journal of Human Genetics. 2022. 109:1-15.
Source: King’s College London, American Journal of Human Genetics