Researchers from the University of Auckland, New Zealand, say they have discovered that a potent new drug restores hearing after noise-induced hearing loss in rats.
They report that injection of an agent called ADAC activates adenosine receptors in cochlear tissues, resulting in recovery of hearing function. If proven, the finding could help pave the way for nonsurgical therapies to restore hearing loss after noise-induced injury.
Srdjan Vlajkovic, PhD, and his team’s work is published in a special edition of Springer’s journal Purinergic Signalling, focusing on the inner ear.
Hearing loss from noise exposure is a leading occupational disease with up to 5% of the population at risk worldwide, according to the researchers. It is particularly common in the military and in industrial settings, with, for example, construction, mining, forestry, and airline industry workers.
Drug therapies for noise-induced hearing loss have only recently been proposed and, to date, there are virtually no treatments that can repair the damage to the inner ear and reduce the impact of hearing loss, according to the researchers.
Vlajkovic and his team’s study investigates the potential of adenosine amine congener (ADAC)–a selective A1 adenosine receptor agonist–in the treatment of noise-induced hearing loss. Wistar rats were exposed to narrow-band noise for two to 24 hours in an acoustic chamber to induce cochlear damage and permanent hearing loss. ADAC or placebo control was then administered by injection(s) in the abdomen, either as a single injection at six hours or multiple daily injections.
The researchers measured the hearing in the rats before and after the treatments using auditory brainstem response (ABR). They also used histological techniques to determine the number of missing cochlear sensory hair cells after noise exposure and the noise-induced production of free radicals.
Their results show that cochlear injury and hearing loss in rats exposed to narrow-band noise can be substantially restored by ADAC administration after noise exposure, say the researchers. Early treatment starting six hours after noise exposure was the most effective and provided greater recovery than late treatment starting 24 hours after noise exposure, they add.
The most sustainable treatment strategy was the one involving multiple injections of ADAC for five days after noise exposure. This therapy significantly attenuated noise-induced hearing loss and improved sensory hair cell survival, the researchers report.
The authors conclude: “This study underpins an important role of adenosine signaling in mitigation of cochlear injury caused by oxidative stress. ADAC in particular emerges as an attractive pharmacological agent for therapeutic interventions in noise-induced cochlear injury in instances of both acute and extended noise exposures.”
Vlajkovic SM et al (2010). Adenosine amine congener mitigates noise-induced cochlear injury. Purinergic Signalling; 10.1007/s11302-010-9188-5
[Source: Springer Science+Business Media]